Article

Post-ischemic inactivation of HIF prolyl hydroxylases in endothelium promotes maladaptive kidney repair by inducing glycolysis

2023-10-03

Abstract excerpt

<h4>ABSTRACT</h4> Ischemic acute kidney injury (AKI) is common in hospitalized patients and increases the risk for chronic kidney disease (CKD). Impaired endothelial cell (EC) functions are thought to contribute in AKI to CKD transition, but the underlying mechanisms remain unclear. Here, we identify a critical role for endothelial oxygen sensing prolyl hydroxylase domain (PHD) enzymes 1-3 in regulating post-isch...

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Literature Corpus work: 932a1c8f-a1ce-53be-afc5-70fe7339b127
DOI: 10.1101/2023.10.03.560700

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