Article

Transcriptomic profiling during normothermic machine perfusion of human kidneys reveals a pro-inflammatory cellular landscape and gene expression signature associated with prolonged delayed graft function after transplantation

2025-03-31

Abstract excerpt

Assessment and treatment of severe ischaemia-reperfusion-injury (IRI) remains an unmet challenge in kidney transplantation. Normothermic machine perfusion (NMP) aims to resuscitate organs but also recapitulates IRI ex situ . Understanding transcriptional pathways, and associated cellular landscape, driving IRI during NMP could facilitate therapeutic targeting. Using tissue and urine from kidneys undergoing NMP pre...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f45dec6f-ef86-5a29-a0dd-7ad60592c4e4
DOI: 10.1101/2025.03.28.25324769

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptomic profiling during normothermic machine perfusion of human kidneys reveals a pro-inflammatory cellular landscape and gene expression signature associated with prolonged delayed graft function after transplantationDOI 10.1101/2025.03.28.25324769Read

A comparative analysis of acellular versus red cell based subnormothermic machine perfusion in human kidney transplantationSemantic proximity Read

Transcriptomic signatures during normothermic liver machine perfusion correspond with graft quality and predict the early graft functionSemantic proximity Read

Investigation of the transcriptional profile of human kidneys during machine perfusion reveals potential benefits of haemoadsorptionSemantic proximity Read

End of preservation normothermic machine perfusion of porcine kidneys after ischaemic injury reprograms metabolism and induces fibrosis after transplant despite unchanged function: insights from the renal proteomeSemantic proximity Read

Hypoxic injury triggers maladaptive repair in human kidney organoidsSemantic proximity Read

Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney diseaseSemantic proximity Read

Identification of ferroptosis-associated genes exhibited in human kidney biopsies after one hour of normothermic machine perfusionSemantic proximity Read

Epithelial-Immune-Stromal Interactions Define Divergent Repair and Fibrosis Pathways After Acute Kidney Injury in Human Renal TransplantsSemantic proximity Read

Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney DiseaseSemantic proximity Read

Transcriptomic responses of the human kidney to acute injury at single cell resolutionSemantic proximity Read

Spatiotemporal transcriptomic analysis during cold ischemic injury to the murine kidney reveals compartment-specific changesSemantic proximity Read

Transcriptional trajectories of human kidney injury progressionSemantic proximity Read