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Spatial metabolomics reveals persistent localized niche-specific metabolic failure in kidneys following ischemia-reperfusion injury

2025-06-01

Abstract excerpt

<h4>ABSTRACT</h4> After acute kidney injury (AKI), the persistence of failed repair proximal tubule (FR-PT) cells is postulated to hamper kidney regeneration and increase the risk of chronic kidney disease. This fibrotic shift likely depends on microenvironmental interactions, which remain largely unstudied. To investigate this, we mapped the spatial metabolic architecture of post-ischemic kidneys using an untarg...

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Literature Corpus work
ab6b09f6-0a53-5072-afbb-ad44fc4e9816
DOI
10.1101/2025.05.27.656326
Open publication

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Spatial metabolomics reveals persistent localized niche-specific metabolic failure in kidneys following ischemia-reperfusion injuryDOI 10.1101/2025.05.27.656326
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