Article

Chromosome compartmentalization replacement during stem cell differentiation

2018-03-18

Abstract excerpt

<h4>ABSTRACT</h4> In this paper, changes in a large-scale 3D structure of chromosomes during stem cell differentiation is studied. The polymer coarse-grained model of a human interphase chromosome is introduced which reproduces the experimental Hi-C contact maps in chromosomes 12, 17 for both embryonic stem and differentiated cells with high accuracy. Model based analysis of Hi-C data suggests a mechanism of esta...

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Literature Corpus work: aeb5fca1-8425-5663-8d5d-64900721d490
DOI: 10.1101/284190

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