Article

Hi-C-constrained physical models of human chromosomes recover functionally-related properties of genome organization

2016-10-17

Abstract excerpt

<h4>ABSTRACT</h4> Combining genome-wide structural models with phenomenological data is at the forefront of efforts to understand the organizational principles regulating the human genome. Here, we use chromosome-chromosome contact data as knowledge- based constraints for large-scale three-dimensional models of the human diploid genome. The resulting models remain minimally entangled and acquire several functiona...

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Literature Corpus work: 5d137262-0957-56a5-8292-d1e618da8a59
DOI: 10.1101/079558

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