Article

Nanoscale 3D DNA tracing in single human cells visualizes loop extrusion directly in situ

2021-04-12

Abstract excerpt

<h4>Summary</h4> The spatial organization of the genome is essential for its functions, including gene expression, DNA replication and repair, as well as chromosome segregation. Biomolecular condensates and loop extrusion have been proposed as the principal driving forces that underlie the formation of chromatin compartments and topologically associating domains, respectively. However, whether the actual 3D-fold...

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Literature Corpus work: 12faeb80-944b-55cf-9f88-633d78c7359b
DOI: 10.1101/2021.04.12.439407

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