Article

Microscopic Chromosomal Structural and Dynamical Origin of Cell Differentiation and Reprogramming

2020-07-17

Abstract excerpt

As an essential and fundamental process of life, cell development involves large-scale reorganization of the three-dimensional genome architecture, which forms the basis of gene regulation. Here, we develop a landscape-switching model to explore the microscopic chromosomal structural origin of the embryonic stem cell (ESC) differentiation and the somatic cell reprogramming. We show that chromosome structure exhibi...

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Literature Corpus work: 7cc7db9a-81ac-50fe-80f5-3fa1fed65187
DOI: 10.1101/2020.07.16.207662

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