Article

Walking along chromosomes with super-resolution imaging, contact maps, and integrative modeling

2018-07-28

Abstract excerpt

Chromosome structure is thought to be crucial for proper functioning of the nucleus. Here, we present a method for visualizing chromosomal DNA at super-resolution and then integrating Hi-C data to produce three-dimensional models of chromosome organization. We begin by applying Oligopaint probes and the single-molecule localization microscopy methods of OligoSTORM and OligoDNA-PAINT to image 8 megabases of human c...

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Literature Corpus work: b67884a5-b94d-514b-a3f3-94b15ebe936c
DOI: 10.1101/374058

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