Article

Generation of dynamic three-dimensional genome structure through phase separation of chromatin

2021-05-07

Abstract excerpt

Three-dimensional genome structure and dynamics play critical roles in regulating DNA functions. Flexible chromatin structure and movements suggested that the genome is dynamically phase-separated to form A (active) and B (inactive) compartments in interphase nuclei. Here, we examined this hypothesis by developing a polymer model of the whole genome of human cells and assessing the impact of phase separation on ge...

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Literature Corpus work: f7bdb696-bcc6-5b4f-a718-fb813965a38e
DOI: 10.1101/2021.05.06.443035

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