Article

Genome Compartmentalization with Nuclear Landmarks: Random yet Precise

2021-11-13

Abstract excerpt

The three-dimensional (3D) organization of eukaryotic genomes plays an important role in genome function. While significant progress has been made in deciphering the folding mechanisms of individual chromosomes, the principles of the dynamic large-scale spatial arrangement of all chromosomes inside the nucleus are poorly understood. We use polymer simulations to model the diploid human genome compartmentalization...

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Literature Corpus work: 09588db3-026c-59a6-95da-2b3bad982a32
DOI: 10.1101/2021.11.12.468401

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