Article

Polymer physics and machine learning reveal a combinatorial code linking chromatin 3D architecture to 1D epigenetics

2021-03-01

Abstract excerpt

<h4>ABSTRACT</h4> The mammalian genome has a complex 3D organization, serving vital functional purposes, yet it remains largely unknown how the multitude of specific DNA contacts, e.g., between transcribed and regulatory regions, is orchestrated by chromatin organizers, such as Transcription Factors. Here, we implement a method combining machine learning and polymer physics to infer from only Hi-C data the genomi...

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Literature Corpus work: 34a87e3b-65d2-57f5-96cb-657eded0ea1d
DOI: 10.1101/2021.03.01.433416

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