Article

Mutational impact of culturing human pluripotent and adult stem cells

2018-09-29

Abstract excerpt

Genetic changes acquired during in vitro culture pose a potential risk for the successful application of stem cells in regenerative medicine. To assess mutation accumulation risks induced by culturing, we determined genetic aberrations in individual human induced pluripotent stem cells (iPS cells) and adult stem cells (ASCs) by whole genome sequencing analyses. Individual iPS cells, intestinal ASCs and liver ASCs...

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Literature Corpus work: ae1c423d-65bb-5c2d-8181-3f3dcbd1e0a2
DOI: 10.1101/430165

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