Article

Early divergence of mutational mechanisms drives genetic heterogeneity of fetal tissues

2018-11-18

Abstract excerpt

A developing human fetus needs to balance rapid cellular expansion with maintaining genomic stability. Here, we accurately quantified and characterized somatic mutation accumulation in fetal tissues by analyzing individual stem cells from human fetal liver and intestine. Fetal mutation rates were ~5-fold higher than in tissue-matched adult stem cells. The mutational landscape of fetal intestinal stem cells resembl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 50424f8c-01b0-5dbd-82b4-43065da63480
DOI: 10.1101/471342

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Early divergence of mutational mechanisms drives genetic heterogeneity of fetal tissuesDOI 10.1101/471342Read

Early divergence of mutational processes in human fetal tissuesSemantic proximity Read

The rate and spectrum of mosaic mutations during embryogenesis revealed by RNA sequencing of 49 tissuesSemantic proximity Read

Clonal dynamics in early human embryogenesis inferred from somatic mutationSemantic proximity Read

Clonal dynamics in early human embryogenesis inferred from somatic mutation.Semantic proximity Read

Prenatal Life is the Predominant Source of Somatic Mosaicism Across Tissues and AgingSemantic proximity Read

Measuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid cultures.Semantic proximity Read

The rate and spectrum of mosaic mutations during embryogenesis revealed by RNA sequencing of 49 tissuesSemantic proximity Read

Prolonged persistence of mutagenic DNA lesions in stem cellsSemantic proximity Read

Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells.Semantic proximity Read

The origins and functional effects of postzygotic mutations throughout the human lifespanSemantic proximity Read

Age-related somatic mutation burden in human tissuesSemantic proximity Read

Somatic genomics as a discovery engine for biomedicine.Semantic proximity Read