Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Stem cell mutations, associated cancer risk, and consequences for regenerative medicine.

Cell stem cell - 2 Nov 2023

Derks Lucca L M, van Boxtel Ruben

Abstract excerpt

Mutation accumulation in stem cells has been associated with cancer risk. However, the presence of numerous mutant clones in healthy tissues has raised the question of what limits cancer initiation. Here, we review recent developments in characterizing mutation accumulation in healthy tissues and compare mutation rates in stem cells during development and adult life with corresponding cancer risk. A certain level...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Genomics and Diagnostics
Share to Carcinogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic factors in colorectal cancer

Share to Mutation

Share to Regenerative Medicine

Share to Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 37832550
DOI: 10.1016/j.stem.2023.09.008
PMCID: PMC10624213

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stem cell mutations, associated cancer risk, and consequences for regenerative medicine.PMID 37832550Read ↗

Stem cell aging and cancer.Semantic proximity Read ↗

Somatic Mutation: What Shapes the Mutational Landscape of Normal Epithelia?Semantic proximity Read ↗

Tissue-specific mutation accumulation in human adult stem cells during lifeSemantic proximity Read ↗

Somatic stem cells and the origin of cancer.Semantic proximity Read ↗

Pathways to tumorigenesis--modeling mutation acquisition in stem cells and their progeny.Semantic proximity Read ↗

Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer.Semantic proximity Read ↗

Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations.Semantic proximity Read ↗

Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention.Semantic proximity Read ↗

Stem cell replication, somatic mutations and role of randomness in the development of cancerSemantic proximity Read ↗

Stem Cell DNA Damage and Genome Mutation in the Context of Aging and Cancer Initiation.Semantic proximity Read ↗

The critical roles of somatic mutations and environmental tumor-promoting agents in cancer risk.Semantic proximity Read ↗

Cancer stem cells: targeting tumors at the source.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.