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Article

Early divergence of mutational processes in human fetal tissues

3 May 2019

Abstract excerpt

A developing human fetus needs to balance rapid cellular expansion with maintaining genomic stability. Here, we accurately quantified and characterized somatic mutation accumulation in fetal tissues by analyzing individual stem cells from human fetal liver and intestine. Fetal mutation rates were about fivefold higher than in tissue-matched adult stem cells. The mutational landscape of fetal intestinal stem cells...

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PMID: 31149636
DOI: 10.1126/sciadv.aaw1271

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