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Article

The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts.

PLoS genetics - 1 Oct 2016

Saini Natalie, Roberts Steven A, Klimczak Leszek J, Chan Kin, Grimm Sara A, Dai Shuangshuang, Fargo David C, Boyer Jayne C, Kaufmann William K, Taylor Jack A, Lee Eunjung, Cortes-Ciriano Isidro, Park Peter J, Schurman Shepherd H, Malc Ewa P, Mieczkowski Piotr A, Gordenin Dmitry A

Abstract excerpt

Accumulation of somatic changes, due to environmental and endogenous lesions, in the human genome is associated with aging and cancer. Understanding the impacts of these processes on mutagenesis is fundamental to understanding the etiology, and improving the prognosis and prevention of cancers and other genetic diseases. Previous methods relying on either the generation of induced pluripotent stem cells, or...

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Identifiers

PMID: 27788131
DOI: 10.1371/journal.pgen.1006385
PMCID: PMC5082821

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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