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Article

Induced Pluripotent Stem Cells: Advances in the Quest for Genetic Stability during Reprogramming Process.

International journal of molecular sciences - 13 Sept 2017

Turinetto Valentina, Orlando Luca, Giachino Claudia

Abstract excerpt

Evaluation of the extent and nature of induced pluripotent stem cell (iPSC) genetic instability is important for both basic research and future clinical use. As previously demonstrated regarding embryonic stem cells, such DNA aberrations might affect the differentiation capacity of the cells and increase their tumorigenicity. Here, we first focus on the contribution of multiple DNA damage response pathways during...

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Cellular Reprogramming
Chromosomal Instability
DNA Damage
DNA Repair
Gene Dosage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genomic Instability

Induced Pluripotent Stem Cells

Oxidative Stress

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Identifiers

PMID: 28902128
DOI: 10.3390/ijms18091952
PMCID: PMC5618601

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