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Somatic mutation load and spectra: A record of DNA damage and repair in healthy human cells.

Environmental and molecular mutagenesis - 1 Oct 2018

Saini Natalie, Gordenin Dmitry A

Abstract excerpt

Somatic genome instability is a hallmark of cancer genomes and has been linked to aging and a variety of other pathologies. Large-scale cancer genome and exome sequencing have revealed that mutation load and spectra in cancers can be influenced by environmental exposures, the anatomical site of exposures, and tissue type. There is now an abundance of data favoring the hypothesis that a substantial portion of the...

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Identifiers

PMID: 30152078
DOI: 10.1002/em.22215
PMCID: PMC6188803

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