Article

Prolonged persistence of mutagenic DNA lesions in stem cells

2023-11-23

Abstract excerpt

<title>Abstract</title> <p>DNA suffers continual damage leaving a cell with thousands of individual DNA lesions at any given moment<sup>1–3</sup>. The efficiency of DNA repair means that most known classes of lesion have a half-life of minutes to hours<sup>3,4</sup>, but whether some DNA damage can persist for longer durations remains unknown. Here, using high-resolution phylogenetic trees from 89 donors, we iden...

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Literature Corpus work: 4a221f0e-e1ff-5297-bf5e-1864bfe8792b
DOI: 10.21203/rs.3.rs-3610927/v1

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