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Article

Insights into the Mutational Burden of Human Induced Pluripotent Stem Cells from an Integrative Multi-Omics Approach.

Cell reports - 24 Jul 2018

D'Antonio Matteo, Benaglio Paola, Jakubosky David, Greenwald William W, Matsui Hiroko, Donovan Margaret K R, Li He, Smith Erin N, D'Antonio-Chronowska Agnieszka, Frazer Kelly A

Abstract excerpt

To understand the mutational burden of human induced pluripotent stem cells (iPSCs), we sequenced genomes of 18 fibroblast-derived iPSC lines and identified different classes of somatic mutations based on structure, origin, and frequency. Copy-number alterations affected 295 kb in each sample and strongly impacted gene expression. UV-damage mutations were present in ∼45% of the iPSCs and accounted for most of the...

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Identifiers

PMID: 30044985
DOI: 10.1016/j.celrep.2018.06.091
PMCID: PMC6467479

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