Article

Insights into the mutational burden of human induced pluripotent stem cells using an integrative omics approach

2018-05-30

Abstract excerpt

<h4>Summary</h4> To understand the mutational burden of human induced pluripotent stem cells (iPSCs), we whole genome sequenced 18 fibroblast-derived iPSC lines and identified different classes of somatic mutations based on structure, origin and frequency. Copy number alterations affected 295 kb in each sample and strongly impacted gene expression. UV-damage mutations were present in ~45% of the iPSCs and account...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 235e7120-b23d-5dd8-87fa-c3a270607a0b
DOI: 10.1101/334870

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Insights into the mutational burden of human induced pluripotent stem cells using an integrative omics approachDOI 10.1101/334870Read

Insights into the Mutational Burden of Human Induced Pluripotent Stem Cells from an Integrative Multi-Omics Approach.Semantic proximity Read

Substantial somatic genomic variation and selection for <i>BCOR</i> mutations in human induced pluripotent stem cellsSemantic proximity Read

Hotspots of De Novo Point Mutations in Induced Pluripotent Stem Cells.Semantic proximity Read

Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells.Semantic proximity Read

iPSCs and fibroblast subclones from the same fibroblast population contain comparable levels of sequence variations.Semantic proximity Read

Optical genome mapping identifies source-associated structural variant differences across early-passage human iPSCsSemantic proximity Read

Single cell whole genome and transcriptome sequencing links somatic mutations to cell identity and ancestrySemantic proximity Read

The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts.Semantic proximity Read

Need for high-resolution Genetic Analysis in iPSC: Results and Lessons from the ForIPS Consortium AuthorsSemantic proximity Read

Mutational impact of culturing human pluripotent and adult stem cellsSemantic proximity Read

Somatic mutation landscape revealed by non-invasive iPSC derivation from urine cellsSemantic proximity Read

Comprehensive Assessment of the Genomic Stability of Human Induced Pluripotent Stem Cells for Clinical ApplicationsSemantic proximity Read