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Article

Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells.

PLoS genetics - 1 Apr 2016

Rouhani Foad J, Nik-Zainal Serena, Wuster Arthur, Li Yilong, Conte Nathalie, Koike-Yusa Hiroko, Kumasaka Natsuhiko, Vallier Ludovic, Yusa Kosuke, Bradley Allan

Abstract excerpt

The accuracy of replicating the genetic code is fundamental. DNA repair mechanisms protect the fidelity of the genome ensuring a low error rate between generations. This sustains the similarity of individuals whilst providing a repertoire of variants for evolution. The mutation rate in the human genome has recently been measured to be 50-70 de novo single nucleotide variants (SNVs) between generations. During...

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Identifiers

PMID: 27054363
DOI: 10.1371/journal.pgen.1005932
PMCID: PMC4824386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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