Article

Pathogen diversity drives the evolution of promiscuous peptide binding of human MHC-II alleles

2018-07-17

Abstract excerpt

Major histocompatibility complex (MHC) molecules mediate the adaptive immune response against pathogens. Certain MHC alleles are generalists: they present an exceptionally large variety of antigenic peptides. However, the functional implications of such elevated epitope binding promiscuity in the MHC molecules are largely unknown. According to what we term the pathogen-driven promiscuity hypothesis, exposure to a...

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Literature Corpus work: ade4f4f5-8ed2-55ea-8c84-e35f4825fdb3
DOI: 10.1101/371054

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