Article

Negative trade-off between neoantigen repertoire breadth and the specificity of HLA-I molecules shapes antitumour immunity

2020-06-26

Abstract excerpt

The human leukocyte antigen class I ( HLA -I) genes shape our immune response against pathogens and cancer. Certain HLA-I variants can bind a much wider range of peptides than others, a feature that could be favorable against a range of viral diseases. However, the implications of this phenomenon on cancer immune response is unknown. In this paper, we quantified peptide repertoire breadth (or promiscuity) of a re...

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Literature Corpus work: 709be1aa-a117-5c0d-b275-d950ca2d0e9f
DOI: 10.1101/2020.06.25.170472

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