A limit to the divergent allele advantage model supported by variable pathogen recognition across HLA-DRB1 allele lineages.

doi:10.1111/tan.12667

Article

A limit to the divergent allele advantage model supported by variable pathogen recognition across HLA-DRB1 allele lineages.

Tissue antigens - 1 Nov 2015

Lau Q, Yasukochi Y, Satta Y

Abstract excerpt

Genetic diversity in human leukocyte antigen (HLA) molecules is thought to have arisen from the co-evolution between host and pathogen and maintained by balancing selection. Heterozygote advantage is a common proposed scenario for maintaining high levels of diversity in HLA genes, and extending from this, the divergent allele advantage (DAA) model suggests that individuals with more divergent HLA alleles bind and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

A limit to the divergent allele advantage model supported by variable pathogen recognition across HLA-DRB1 allele lineages.

Abstract excerpt

Topics

A limit to the divergent allele advantage model supported by variable pathogen recognition across HLA-DRB1 allele lineages.

Abstract excerpt

Topics

Related research