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Article

Signatures of historical demography and pathogen richness on MHC class I genes.

Immunogenetics - 1 Mar 2012

Qutob Nouar, Balloux Francois, Raj Towfique, Liu Hua, Marion de Procé Sophie, Trowsdale John, Manica Andrea

Abstract excerpt

The extreme polymorphism of MHC class I has been argued to be driven by balancing selection from pathogens, with the prediction that populations exposed to a wider variety of diseases should have higher diversity. We assembled a global database of allotype frequencies for MHC class I genes and investigated possible drivers of genetic diversity, measured in different ways. We first looked for a decline in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21947542
DOI: 10.1007/s00251-011-0576-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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