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Article

Pathogen-driven selection and worldwide HLA class I diversity.

Current biology : CB - 7 Jun 2005

Prugnolle Franck, Manica Andrea, Charpentier Marie, Guégan Jean François, Guernier Vanina, Balloux François

Abstract excerpt

The human leukocyte antigen (HLA; known as MHC in other vertebrates) plays a central role in the recognition and presentation of antigens to the immune system and represents the most polymorphic gene cluster in the human genome [1]. Pathogen-driven balancing selection (PDBS) has been previously hypothesized to explain the remarkable polymorphism in the HLA complex, but there is, as yet, no direct support for this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15936272
DOI: 10.1016/j.cub.2005.04.050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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