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Article

Unique Pathogen Peptidomes Facilitate Pathogen-Specific Selection and Specialization of MHC Alleles.

Molecular biology and evolution - 27 Sept 2021

Özer Onur, Lenz Tobias L

Abstract excerpt

A key component of pathogen-specific adaptive immunity in vertebrates is the presentation of pathogen-derived antigenic peptides by major histocompatibility complex (MHC) molecules. The excessive polymorphism observed at MHC genes is widely presumed to result from the need to recognize diverse pathogens, a process called pathogen-driven balancing selection. This process assumes that pathogens differ in their...

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PMID: 34110412
DOI: 10.1093/molbev/msab176
PMCID: PMC8476153

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