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Article

Advances in the Evolutionary Understanding of MHC Polymorphism.

Trends in genetics : TIG - 1 Apr 2020

Radwan Jacek, Babik Wiesław, Kaufman Jim, Lenz Tobias L, Winternitz Jamie

Abstract excerpt

Proteins encoded by the classical major histocompatibility complex (MHC) genes incite the vertebrate adaptive immune response by presenting peptide antigens on the cell surface. Here, we review mechanisms explaining landmark features of these genes: extreme polymorphism, excess of nonsynonymous changes in peptide-binding domains, and long gene genealogies. Recent studies provide evidence that these features may...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 32044115
DOI: 10.1016/j.tig.2020.01.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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