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Article

Divergent Allele Advantage at Human MHC Genes: Signatures of Past and Ongoing Selection.

Molecular biology and evolution - 1 Sept 2018

Pierini Federica, Lenz Tobias L

Abstract excerpt

The highly polymorphic genes of the major histocompatibility complex (MHC) play a key role in adaptive immunity. Divergent allele advantage, a mechanism of balancing selection, is proposed to contribute to their exceptional polymorphism. It assumes that MHC genotypes with more divergent alleles allow for broader antigen-presentation to immune effector cells, by that increasing immunocompetence. However, the...

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Identifiers

PMID: 29893875
DOI: 10.1093/molbev/msy116
PMCID: PMC6106954

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