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Article

HLA-II peptide-binding diversity shapes humoral immune responses and susceptibility to infections.

Nature communications - 5 Aug 2026

Magyari Bettina, Fülöp Anna Tácia, Kókai Dávid, Tóth Franciska, Balogh Gergő Mihály, Andreu-Sánchez Sergio, Innocenti Gabriel, Weersma Rinse K, Fu Jingyuan, Pál Csaba, Zhernakova Alexandra, Vogl Thomas, Manczinger Máté

Abstract excerpt

Infectious diseases represent a leading cause of mortality worldwide and have shaped the evolution of the human immune system. Human leukocyte antigen (HLA) class II molecules are key to the humoral immune response by presenting peptides to helper T cells. The peptide-binding range varies greatly among HLA-II variants, but the role of this variation in humoral immunity and infection susceptibility has remained...

Read the complete abstract on PubMed

Topics

Humans
Immunity, Humoral
Peptides
Disease Susceptibility
Histocompatibility Antigens Class II

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Protein Binding

Source

Open in PubMed Open full text

Identifiers

PMID: 42686785
DOI: 10.1038/s41467-026-76184-1
PMCID: PMC13538663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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