Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct evolutionary strategies of human leucocyte antigen loci in pathogen-rich environments.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 19 Mar 2012

Sanchez-Mazas Alicia, Lemaître Jean-François, Currat Mathias

Abstract excerpt

Human leucocyte antigen (HLA) loci have a complex evolution where both stochastic (e.g. genetic drift) and deterministic (natural selection) forces are involved. Owing to their extraordinary level of polymorphism, HLA genes are useful markers for reconstructing human settlement history. However, HLA variation often deviates significantly from neutral expectations towards an excess of genetic diversity. Because...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Emigration and Immigration
Share to Genetic Drift

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Geography

Share to History, Ancient

Share to HLA Antigens

Share to Host-Pathogen Interactions

Share to Immunogenetic Phenomena

Share to Linear Models

Source

Open in PubMed Open full text

Identifiers

PMID: 22312050
DOI: 10.1098/rstb.2011.0312
PMCID: PMC3267122

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct evolutionary strategies of human leucocyte antigen loci in pathogen-rich environments.PMID 22312050Read ↗

Pathogen-driven selection and worldwide HLA class I diversity.Semantic proximity Read ↗

HLA DNA sequence variation among human populations: molecular signatures of demographic and selective events.Semantic proximity Read ↗

A limit to the divergent allele advantage model supported by variable pathogen recognition across HLA-DRB1 allele lineages.Semantic proximity Read ↗

Balancing selection and heterogeneity across the classical human leukocyte antigen loci: a meta-analytic review of 497 population studies.Semantic proximity Read ↗

HLA class I haplotype diversity is consistent with selection for frequent existing haplotypes.Semantic proximity Read ↗

Pathogen diversity drives the evolution of promiscuous peptide binding of human MHC-II allelesSemantic proximity Read ↗

Divergent Allele Advantage at Human MHC Genes: Signatures of Past and Ongoing Selection.Semantic proximity Read ↗

Signatures of historical demography and pathogen richness on MHC class I genes.Semantic proximity Read ↗

Tracking human migrations by the analysis of the distribution of HLA alleles, lineages and haplotypes in closed and open populations.Semantic proximity Read ↗

Drivers of immune-related genetic variation across human populationsSemantic proximity Read ↗

A sequence-based approach demonstrates that balancing selection in classical human leukocyte antigen (HLA) loci is asymmetric.Semantic proximity Read ↗

A review of HLA allele and SNP associations with highly prevalent infectious diseases in human populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.