Article

Ancient Trans-Species Polymorphism at the Major Histocompatibility Complex in Primates

2022-06-29

Abstract excerpt

Classical genes within the Major Histocompatibility Complex (MHC) are responsible for peptide presentation to T cells, thus playing a central role in immune defense against pathogens. These genes are subject to strong selective pressures including both balancing and directional selection, resulting in exceptional genetic diversity—thousands of alleles per gene in humans. Moreover, some allelic lineages appear to b...

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Literature Corpus work: 89a45326-19b6-50d2-99f6-6c3650477efd
DOI: 10.1101/2022.06.28.497781

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