Article

Joint decomposition of Hi-C maps reveals salient features of genome architecture across tissues and development

2025-08-07

Abstract excerpt

The spatial organization of chromosomes in the nucleus is fundamental to cellular processes. Contact frequency maps from Hi-C and related chromosome conformation capture assays are increasingly available for a wide variety of biosamples and conditions, creating opportunities for comprehensive studies of genome compartmentalization and long-range interactions. However, the conventional dimensionality reduction appr...

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Literature Corpus work: 95335fe6-c5ad-5bfc-9f48-0acce5312355
DOI: 10.1101/2025.08.07.669116

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