Article

Loop-extrusion and polymer phase-separation can co-exist at the single-molecule level to shape chromatin folding

2021-11-02

Abstract excerpt

Loop-extrusion and phase-separation have been proposed as mechanisms that shape chromosome large-scale spatial organization. It is unclear, however, how they perform relative to each other in explaining chromatin architecture data and whether they compete or co-exist at the single-molecule level. Here, we compare models of polymer physics based on loop-extrusion and phase-separation, as well as models where both m...

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Literature Corpus work: 7d4ff7de-8fd0-573f-a9f6-3bb7ba67ede5
DOI: 10.1101/2021.11.02.466589

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