Article

Polymer physics models reveal structural folding features of single-molecule gene chromatin conformations

2024-07-16

Abstract excerpt

Here, we employ polymer physics models of chromatin to investigate the 3D folding of a 2Mb wide genomic region encompassing the human LTN1 gene, a crucial DNA locus involved in key cellular functions. Through extensive Molecular Dynamics simulations, we reconstruct in-silico the ensemble of single-molecule LTN1 3D structures, which we benchmark against recent in-situ Hi-C 2.0 data. The model-derived single molec...

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Literature Corpus work: 8128b7a5-5e31-5f9d-866e-e417f121368a
DOI: 10.1101/2024.07.16.603769

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