Article

Exploring Chromosomal Structural Heterogeneity Across Multiple Cell Lines

2020-03-22

Abstract excerpt

We study the structural ensembles of human chromosomes across different cell types. Using computer simulations, we generate cell-specific 3D chromosomal structures and compare them to recently published chromatin structures obtained through microscopy. We demonstrate using a combination of machine learning and polymer physics simulations that epigenetic information can be used to predict the structural ensembles o...

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Literature Corpus work: 40016adb-2805-5ba0-926d-7437fa788028
DOI: 10.1101/2020.03.21.001917

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