Article

Uncovering High-Resolution Organization of Genomic Loci using Experimentally Informed Polymer Model

2025-11-20

Abstract excerpt

The functionality of an organism depends on gene expression patterns, which are governed by the hierarchical organization of the genome. Numerous efforts, leveraging both polymer physics-based models and experimental imaging technologies, have sought to elucidate the structure-function relationship of chromatin fibers. However, a major challenge remains: the intrinsically multi-scale nature of chromatin organizati...

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Literature Corpus work: 7d2cd691-d5ee-5015-b65e-18c0d012139d
DOI: 10.1101/2025.11.19.689404

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