Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional dissection of noncoding variants associated with rheumatoid arthritis.

Annals of the rheumatic diseases - 1 Jul 2025

Jajodia Ajay, Mishra Arpit, Doni Jayavelu Naresh, Lambert Katharina, Moss Nicholas, Yang Zongchen, Cerosaletti Karen, Buckner Jane H, Hawkins R David

Abstract excerpt

OBJECTIVES: Noncoding variants are critical to our understanding of the genetic basis of diseases and disorders such as rheumatoid arthritis (RA). While genome-wide association studies have identified regions of the genome associated with disease, functional studies are still lagging that can identify potentially causative variants. METHODS: In order to functionally fine-map RA-associated variants, we identified...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis, Rheumatoid
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genetic Variation

Share to Genome-Wide Association Study

Share to Genotype

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 40318978
DOI: 10.1016/j.ard.2025.04.001
PMCID: PMC13127724

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional dissection of noncoding variants associated with rheumatoid arthritis.PMID 40318978Read ↗

Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis.Semantic proximity Read ↗

Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritisSemantic proximity Read ↗

Single-cell CRISPR activation screens in primary B cells discover gene regulatory mechanisms for hundreds of autoimmune risk lociSemantic proximity Read ↗

Translating GWAS in rheumatic disease: approaches to establishing mechanism and function for genetic associations with ankylosing spondylitis.Semantic proximity Read ↗

Update on the genetic architecture of rheumatoid arthritis.Semantic proximity Read ↗

Enrichment of Genetic Variants for Rheumatoid Arthritis within T-Cell and NK-Cell Enhancer Regions.Semantic proximity Read ↗

Genome editing to define the function of risk loci and variants in rheumatic disease.Semantic proximity Read ↗

Genetics of rheumatoid arthritis contributes to biology and drug discovery.Semantic proximity Read ↗

CRISPRa screen on a genetic risk locus shared by multiple autoimmune diseases identifies a dysfunctional enhancer that affects <i>IRF8</i> expression through cooperative lncRNA and DNA methylation machinerySemantic proximity Read ↗

Discovery of an autoimmunity-associated <i>IL2RA</i> enhancer by unbiased targeting of transcriptional activationSemantic proximity Read ↗

A multilayered post-GWAS analysis pipeline defines functional variants and target genes for systemic lupus erythematosus (SLE)Semantic proximity Read ↗

Identification of causal genes and mechanisms by which genetic variation mediates juvenile idiopathic arthritis susceptibility using functional genomics and CRISPR-Cas9Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.