Article

The Chromatin Landscape of Pathogenic Transcriptional Cell States in Rheumatoid Arthritis

2023-04-08

Abstract excerpt

Synovial tissue inflammation is the hallmark of rheumatoid arthritis (RA). Recent work has identified prominent pathogenic cell states in inflamed RA synovial tissue, such as T peripheral helper cells; however, the epigenetic regulation of these states has yet to be defined. We measured genome-wide open chromatin at single cell resolution from 30 synovial tissue samples, including 12 samples with transcriptional d...

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Literature Corpus work: 0eddb078-d60f-5493-a240-002441c03dcb
DOI: 10.1101/2023.04.07.536026

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