Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis

31 May 2024

Abstract excerpt

Synovial tissue inflammation is a hallmark of rheumatoid arthritis (RA). Recent work has identified prominent pathogenic cell states in inflamed RA synovial tissue, such as T peripheral helper cells; however, the epigenetic regulation of these states has yet to be defined. Here, we examine genome-wide open chromatin at single-cell resolution in 30 synovial tissue samples, including 12 samples with transcriptional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to T-cell and B-cell Immunology
Share to Chronic Lymphocytic Leukemia Research
Share to Lymphoma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38821936
DOI: 10.1038/s41467-024-48620-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritisPMID 38821936Read ↗

The Chromatin Landscape of Pathogenic Transcriptional Cell States in Rheumatoid ArthritisSemantic proximity Read ↗

Dynamic regulatory elements in single-cell multimodal data capture autoimmune disease heritability and implicate key immune cell statesSemantic proximity Read ↗

Multi-lineage transcriptional and cell communication signatures define pathways in individuals at-risk for developing rheumatoid arthritis that initiate and perpetuate diseaseSemantic proximity Read ↗

Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritisSemantic proximity Read ↗

Multi-lineage transcriptional and cell communication signatures define evolving personalized mechanisms that initiate and perpetuate rheumatoid arthritisSemantic proximity Read ↗

Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis.Semantic proximity Read ↗

The chromatin landscape of Th17 cells reveals mechanisms of diversification of regulatory and pro-inflammatory statesSemantic proximity Read ↗

Gene-regulatory network study of rheumatoid arthritis in single-cell chromatin landscapes of peripheral blood mononuclear cellsSemantic proximity Read ↗

Defining Inflammatory Cell States in Rheumatoid Arthritis Joint Synovial Tissues by Integrating Single-cell Transcriptomics and Mass CytometrySemantic proximity Read ↗

Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processesSemantic proximity Read ↗

Cellular deconstruction of inflamed synovium defines diverse inflammatory phenotypes in rheumatoid arthritisSemantic proximity Read ↗

The Chromatin Accessibility Landscape of Peripheral Blood Mononuclear Cells in Patients With Systemic Lupus Erythematosus at Single-Cell ResolutionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.