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Transcription factors use a unique combination of cofactors to potentiate different promoter-dependent steps in transcription

2022-10-25

Abstract excerpt

Transcription factors use DNA binding domains to recognise specific sequences and transactivation domains to recruit the cofactor proteins necessary for transcription. However, how specific cofactors contribute to transactivation at different genes remains unclear. Here, we couple Gal4-transactivation assays with comparative CRISPR-Cas9 screens to identify the cofactors required by nine different transcription fac...

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Identifiers and source

Literature Corpus work
14633857-fd0d-5947-b1ad-b8f963d665bd
DOI
10.1101/2022.10.25.513774
Open publication

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Transcription factors use a unique combination of cofactors to potentiate different promoter-dependent steps in transcriptionDOI 10.1101/2022.10.25.513774
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