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Small-molecule inducible transcriptional control in mammalian cells

30 Aug 2020

Abstract excerpt

Tools for tuning transcription in mammalian cells have broad applications, from basic biological discovery to human gene therapy. While precise control over target gene transcription via dosing with small molecules (drugs) is highly sought, the design of such inducible systems that meets required performance metrics poses a great challenge in mammalian cell synthetic biology. Important characteristics include...

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PMID: 32862714
DOI: 10.1080/07388551.2020.1808583

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