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Article

Inducible, tunable and multiplex human gene regulation using CRISPR-Cpf1-based transcription factors

2017-06-15

Abstract excerpt

<h4>ABSTRACT</h4> Targeted and inducible regulation of mammalian gene expression is a broadly important research capability that may also enable development of novel therapeutics for treating human diseases. Here we demonstrate that a catalytically inactive RNA-guided CRISPR-Cpf1 nuclease fused to transcriptional activation domains can up-regulate endogenous human gene expression. We engineered drug-inducible Cpf...

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Literature Corpus work
90ad070f-56b8-52a5-8f5e-4b80e5758f84
DOI
10.1101/150656
Open publication

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Inducible, tunable and multiplex human gene regulation using CRISPR-Cpf1-based transcription factorsDOI 10.1101/150656
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