Article

The UV potentiated mutational signature of clinical stage G-quadruplex binder CX5461

2026-04-14

Abstract excerpt

Drug-related UVA-induced photoreactions have been reported for several therapeutic compounds, including fluoroquinolones. CX5461 is a clinically relevant quinolone-derived anti-cancer small molecule with documented UVA-sensitising activity. Here we compared, by bulk and clonal whole genome sequencing (WGS) under light-protected conditions, the mutational signatures in human retinal pigment epithelial cells (RPE1)...

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Literature Corpus work: a8499bcb-a8ed-52a4-b296-38973b4a2efd
DOI: 10.64898/2026.04.10.717570

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