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Article

Genome-wide mutation spectra of canonical and atypical UV photoproducts in S. cerevisiae.

Nucleic acids research - 20 May 2026

Laughery Marian F, Haueter Jamison C, Patchett Hailey N, Mieczkowski Piotr A, Roberts Steven A, Wyrick John J

Abstract excerpt

UV exposure causes not only cytosine-to-thymine (C > T) substitutions in dipyrimidine sequences but also many non-canonical mutation classes (e.g. A > T, T > C, and AC > TT). While C > T substitutions are thought to arise from mutagenic bypass of cyclobutane pyrimidine dimers (CPDs), the photoproduct(s) that cause non-canonical mutation classes, which are responsible for key driver mutations in melanoma, are...

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Identifiers

PMID: 42165128
DOI: 10.1093/nar/gkag482
PMCID: PMC13187834

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CPD

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