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Article

UVA-induced DNA damage and mutations in human melanocytes: relevance for melanoma mutations.

Nucleic acids research - 5 Sept 2025

Jin Seung-Gi, Johnson Jennifer, Kim Paul Y, Pfeifer Gerd P

Abstract excerpt

UVB radiation (280-320 nm) from sunlight induces skin cancer through DNA damage-induced mutations. Melanomas carry mutational signatures associated with UVB-induced cyclobutane pyrimidine dimers (CPDs). However, there are several other melanoma signatures of unknown origin. To test if these signatures are linked to UVA, we exposed human melanocytes to UVA (340-400 nm) and to UVB for comparison. We mapped DNA...

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Identifiers

PMID: 40966495
DOI: 10.1093/nar/gkaf905
PMCID: PMC12445662

Genes

CPD

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