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Article

Biochemical and photochemical mechanisms that produce different UV-induced mutation spectra.

Mutation research - 1 Jan 2000

Sugiyama Tomohiko, Keinard Brianna, Best Griffin, Sanyal Mahima R

Abstract excerpt

Although UV-induced mutagenesis has been studied extensively, the precise mechanisms that convert UV-induced DNA damage into mutations remain elusive. One well-studied mechanism involves DNA polymerase (Pol) η and ζ, which produces C > T transitions during translesion synthesis (TLS) across pyrimidine dimers. We previously proposed another biochemical mechanism that involves multiple UV-irradiations with...

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Identifiers

PMID: 34563793
DOI: 10.1016/j.mrfmmm.2021.111762
PMCID: PMC8671204

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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