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Characterization of the phototoxicity, chemigenetic profile, and mutational signatures of the chemotherapeutic CX-5461 in <i>Caenorhabditis elegans</i>

2019-12-23

Abstract excerpt

<h4>ABSTRACT</h4> New anti-cancer therapeutics require extensive in vivo characterization to identify endogenous and exogenous factors affecting efficacy, to measure toxicity and mutagenicity, and to determine genotypes resulting in therapeutic sensitivity or resistance. We used Caenorhabditis elegans as a platform with which to characterize properties of anti-cancer therapeutic agents in vivo . We generated a...

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Literature Corpus work
382f364c-20ae-5b54-a11a-4eebe7bdea07
DOI
10.1101/2019.12.20.884981
Open publication

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