Article

Reply to: The chemotherapeutic drug CX-5461 is a potent mutagen in cultured human cells

2025-10-01

Abstract excerpt

Replying to GCC Koh et al., Nature Genetics ( www.nature.com/articles/s41588-023-01602-9 ) and the comments by Simon Boulton in Nature Genetics ( www.nature.com/articles/s41588-023-01611-8 ). The drug CX-5461 [Pidnarulex] is an inhibitor of RNA polymerase I and topoisomerase II and a DNA G-quadruplex stabilizer. Koh et al. recently reported that CX-5461 induces extensive, non-selective collateral mutagenesis i...

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Literature Corpus work: 4dea5cba-5ff9-5a29-ade1-42f1c9e6d8a3
DOI: 10.1101/2025.09.30.25336525

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